Association between interleukin‑10 (rs1800871) gene polymorphism and patients with chronic periodontitis

Ali S. Shakir1, Zahraa Fawwaz2, Sarah Kather Majeed2, Manar Fouad2, Diyer F. Murad2,
Saba Hameed Alshebani2
1Lecturer of Clinical Immunology, Department of Basic Sciences, College of Dentistry, University of Al
Qadisiyah, Diwaniyah, Iraq
2College of Dentistry, University of Al-Qadisiyah, Diwaniyah, Iraq

Abstract
Background: Interleukin-10 (IL-10) is a non-inflammatory cytokine, and has a positive association with
periodontitis. IL-10 (rs1800871) polymorphisms in the IL-10 site have been linked with variable
expression. Aim: Goal of this search was to study a link amidst the polymorphisms of these genes and
deep-seated of gum disease in Iraqi patients. Methods: 120 blood specimen were collected, 60 of which
were from patients with chronic periodontitis and 60 from healthy controls for comparison. Polymerase
chain reaction-restriction fragment length polymorphism (PCR) for purpose of analyze IL-10 (rs1800871).
Chi-square test was used to statistically analyze the data. Problems related to individual alleles, genotypes,
and phenotypes were identified by various logistic regression test to determine odds ratio (OR) and 95%
confidence interval (CI). P < 0.05 is significant. Results: Prevalence of TC, CC genotypes of IL10‑819
were importantly various amidst CP and healthy in simile with TT genotype (OR = 9.72; CI = 3.36–24.4;
P = 0.001 for C vs. TT, OR = 5.41; CI = 1.8–8.14; P < 0.001 for TC vs. TT). In addendum, themes with
at minimum one IL10‑819‑C allele were importantly had high danger for CP (OR = 6.2; CI = 3.52–10.8;
P < 0.001). Conclusion: Our results concluded the IL-10 gene polymorphism (-819T/C) is potential to
be a danger agent for chronic periodontitis in Iraqi patients.
Keyword: Advanced gingivitis, IL-10, cytokines, PCR, polymorphisms

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