Hematological Fluctuations in parathyroid hormone in chronic kidney disease patients undergoing hemodialysis

Zahraa N. K. Al Aboudi , Huda B. Hussein
Department of Biology, College of Education for Pure Sciences, University of Wasit, Wasit, Iraq

Abstract:
Different causes of significant useful and structural kidney disabilities are also called CRF. The main ones
are blood with low calcium level and high phosphorus level. It is responsible for several health problems,
including osteoporosis, atherosclerosis as well as nervous system issues. The aim of the present study was
to evaluate calcium and phosphor variability in hemodialysis patients with CKD and anticipated health
effects. Total number of samples = 100, which includes 100 patients ( clinically and biochemically
diagnosed to have renal failure and subjected to dialysis _) along with the bio- data collection of 50 adult
healthy volunteers. Regarding sex distribution, the study of our patient group included 60 males (60%)
and 40 females (40%). The study’s results showed that the mean of parathyroid hormone concentrations
was (376.166pg/ml) in 94% of the sample after dialysis session and it is demonstrated a very significant
increase in blood phosphorus levels for CKD patients compared to reference values (>4.5 mg/dL).
Approximately 80% of Patients with chronic renal failure have increased phosphorus levels versus 20
percentile fall within normal reference interval. In contrast, 60% of patients present with hypocalcemia
(<8.5 mg/dL). It is known that in prior studies a significant association between calcium and phosphor
with parathyroid hormones has been shown, there is strong positive correlation of high phosphorus level
(hyperphosphatemia) with highly increased activity of PTH in hemodialysis patients, retention of
phosphorus and lack of active vitamin D promotes the glands to secrete more hormone causing bone and
cardiovascular complications. Dietary and therapeutic control of phosphorus is essential.

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