Abbas Ali Manshd
Department of Medical laboratories, College of Health & Medical Technology, Sawa University,
Almuthanna, Iraq

Abstract
Background: Infertility defines as the inability to get pregnant after 12 months of unprotected sexual
activity. In a healthy testis, the spermatogonia cells, sertoli cells, interstitial cells, and immune cells
secrete cytokines that act as intracellular signals to control the differentiation and development of
hormones that control reproduction, testicular function, germ cells, and spermatogenesis. Male infertility
can result from impaired cytokine production, which can impact how the reproductive system works.
Objective: The present study was conducted to estimation of the potential role of proinflammatory
cytokines (Interleukin-6 and Interleukin-17) in male idiopathic infertility. Methods: This study was
conducted on fifty male infertile patients who were admitted to hospital from the period November
/2023 – May/ 2024 and another group consisting of 50 apparently healthy individuals used as controls.
Results: The results demonstrated significant elevation of Interleukin-6 and Interleukin-17 levels in the
patients group (azoospermia and oligospermia) (14.52±6.27; 12.3±5.76); (15.65±5.32; 13.6±4.42)
respectively, when compared with those of control group (7.83±0.61; 6.52±0.75), respectively.
Conclusion: Interleukin-6 and Interleukin-17 can be as diagnostic and prognostic biomarker give more
accuracy and precise results.

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