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May 31, 2026Israa makki alwaan1
Kadhim aabar sharhan2
1 Babil Health Directorate,Al-Kartiyaprimary Health Center Babil, Iraq
2 Public Health Laboratory, Maysan Health Directorate, Maysan, Iraq
Abstract
Background:
Managing postprandial hyperglycemia is an important target for the treatment of type 2 diabetes mellitus
(t2dm). One strategy is to reduce the activity of enzymes responsible for carbohydrate digestion, such as
α-amylase and α-glucosidase. In recent years, natural polyphenols like catechin and epicatechin have been
studied for their potential metabolic effects. Experimental data suggest potential impacts on glucose
metabolism and insulin sensitivity; however, evidence from integrated human models is limited and needs
further clarification.
Objective:
this study examined the effects of catechin and epicatechin supplementation on digestive enzyme activity
and glycemic control in individuals with type 2 diabetes, using response surface methodology to analyze
metabolic interactions.
Methods:
in a central composite design study, 192 participants (diabetic and healthy) received 200 mg/day of
catechins (100 mg catechin and 100 mg epicatechin twice daily) for 45 days. Fasting serum samples were
analyzed for α-amylase, α-glucosidase, and β-glucosidase activities, as well as glucose and insulin levels.
Serum underwent dialysis and sequential molecular weight filtration before rp-hplc separation on a c18
column. Enzyme activity was determined spectrophotometrically, and insulin concentrations by elisa. A
desirability function, based on the geometric mean of individual outcomes, summarized the overall
metabolic response. Anova and goodness-of-fit indicators assessed model performance.
